A Postdoctoral Fellow position is available in the Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX, United States. This position reports to Dr. Palaniraja Thandapani in the Department of Hematopoietic Biology & Malignancy. The major focus of the lab is to study tRNA expression and epitranscriptomic regulation of gene expression in normal and malignant hematopoiesis. We had recently identified altered tRNA biogenesis as an indicator of tumor specific amino acid demand for protein synthesis in T-cell acute lymphoblastic leukemia (T-ALL) (https://www.nature.com/articles/s41586-021-04244-1). These results have revealed that understanding tRNA deregulation can reveal novel targetable dependencies in tumors.

Emphasis and time will be committed to mentoring along with laying clear goals and timelines for successful transitions to academic or industry positions for the fellow in accordance with their evolving preferences. Perfect for candidates seeking direct mentorship from a young investigator, while obtaining the support of senior PIs in the Department of Hematopoietic Biology & Malignancy and the Division of Cancer Medicine at MDACC. MDACC is part of the dynamic UT Medical scientific community located in the very affordable Houston metropolis.

LEARNING OBJECTIVES

To explore the role of tRNA deregulation in blood malignancies, the lab will utilize MDACC's rich resources in human samples and patient-derived tumor models and apply novel approaches (Next Gen Sequencing, Nanopore sequencing) to profile tRNA expression and epitranscriptomic changes across leukemia subtypes, normal hematopoietic subsets and integrate this information with functional CRISPR screens, mechanistic studies and novel approaches (dietary, RNA therapeutics, synthetic lethality) to gain insights into tRNA deregulation and develop novel therapies for hematological malignancies.

-Lead computationally focused scientific research projects with moderate supervision from the PI. Provide inputs regarding analytical approaches, set up analyses, and develop new computational research methods. Instruct and guide other staff in basic computational research techniques and procedures.

-Experience analyzing and interpreting NGS data such as RNA-seq, Chip-Seq, Ribo-Seq. Any prior experience in analyzing ONT data will be helpful. Proficient in programming languages such as Python, R, Java, Matlab.

-Knowledge of CRISPR systems and experience in designing CRISPR libraries.

ELIGIBILITY REQUIREMENTS

Highly motivated individuals with a Ph.D. in Biology, Bioinformatics, Computer Science, or related areas are encouraged to apply. A proven track record of publications and excellent written and oral communication skills are required.

POSITION INFORMATION

MD Anderson follows the NIH stipend levels as outlined by the Kirchstein - NRSA (https://grants.nih.gov/grants/guide/notice-files/NOT-OD-23-076.html) . This full-time trainee position will provide a salary between $56,484 to $68,604, dependent upon the years of postgraduate experience.

MD Anderson offers compensated trainees:

• Paid medical benefits (zero premium) starting on first day for trainees who work 30 or more hours per week

• Group Dental, Vision, Life, AD&D and Disability coverage

• Paid Education Vacation and Sick Leave

• Paid institutional holidays, wellness leave, childcare leave and other paid leave programs

• Teachers Retirement System defined-benefit pension plan and two voluntary retirement plans

• Employer paid life, AD&D and an illness-related reduced salary pay program

• Health Savings Account and Dependent Care Reimbursement flexible spending accounts

• Fertility benefits

• State of Texas longevity pay

• Extensive wellness, fitness, employee health programs and employee resource groups

FACULTY MENTOR

Palaniraja Thandapani